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The Medicine Portal

The color fresco Care of The Sick by Domenico di Bartolo, 1441–1442, depicting the Santa Maria della Scala hospital in Siena, Italy

Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of creativity and skill), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic and applied, under the umbrella of medical science). For example, while stitching technique for sutures is an art learned through practice, knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science.

Prescientific forms of medicine, now known as traditional medicine or folk medicine, remain commonly used in the absence of scientific medicine and are thus called alternative medicine. Alternative treatments outside of scientific medicine with ethical, safety and efficacy concerns are termed quackery. (Full article...)

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  • Image 1 Portrait by Max Büttinghausen, 1895–1905 Aletta Henriëtte Jacobs (Dutch pronunciation: [aːˈlɛtaː ɦɑ̃ːriˈjɛtə ˈjaːkɔps]; 9 February 1854 – 10 August 1929) was a Dutch physician and women's suffrage activist. As the first woman officially to attend a Dutch university, she became one of the first female physicians in the Netherlands. In 1882, she founded the world's first birth control clinic and was a leader in both the Dutch and international women's movements. She led campaigns aimed at deregulating prostitution, improving women's working conditions, promoting peace and calling for women's right to vote. Born in the mid-nineteenth century, Jacobs yearned to become a doctor like her father. Despite existing barriers, she fought to gain entry to higher education and graduated in 1879 with the first doctorate in medicine earned by a woman in the Netherlands. Providing medical services to women and children, she grew concerned over the health of working women, recognizing that as laws did not provide adequate protection for their health, their economic stability was compromised. She opened a free clinic to educate poor women about hygiene and child care and in 1882 expanded her services to include distribution of contraception information and devices. Though she continued to practice medicine until 1903, Jacobs increasingly turned her attention to activism with a view to improving women's lives. (Full article...)

    Portrait by Max Büttinghausen, 1895–1905

    Aletta Henriëtte Jacobs (Dutch pronunciation: [aːˈlɛtaː ɦɑ̃ːriˈjɛtə ˈjaːkɔps]; 9 February 1854 – 10 August 1929) was a Dutch physician and women's suffrage activist. As the first woman officially to attend a Dutch university, she became one of the first female physicians in the Netherlands. In 1882, she founded the world's first birth control clinic and was a leader in both the Dutch and international women's movements. She led campaigns aimed at deregulating prostitution, improving women's working conditions, promoting peace and calling for women's right to vote.

    Born in the mid-nineteenth century, Jacobs yearned to become a doctor like her father. Despite existing barriers, she fought to gain entry to higher education and graduated in 1879 with the first doctorate in medicine earned by a woman in the Netherlands. Providing medical services to women and children, she grew concerned over the health of working women, recognizing that as laws did not provide adequate protection for their health, their economic stability was compromised. She opened a free clinic to educate poor women about hygiene and child care and in 1882 expanded her services to include distribution of contraception information and devices. Though she continued to practice medicine until 1903, Jacobs increasingly turned her attention to activism with a view to improving women's lives. (Full article...)
  • Image 2 Mayo Foundation v. United States, 562 U.S. 44 (2011), is a United States Supreme Court case in which the Court upheld a Treasury Department regulation on the grounds that the courts should defer to government agencies in tax cases in absence of an unreasonable decision on the part of the agency. Under the Federal Insurance Contributions Act (FICA), students and their educational employers are exempted from paying Social Security taxes. The Treasury Department issued a regulation in 2004, declaring those who worked more than 40 hours a week were ineligible for such an exemption. The Mayo Foundation filed suit to challenge the regulation and for a refund of the taxes it had paid on its medical residents—recently graduated physicians, who work more than full-time providing patient care but who are still considered trainees by the medical profession. The District Court ruled for the Mayo Foundation and struck the regulation, but was reversed by the Court of Appeals. (Full article...)
    Mayo Foundation v. United States, 562 U.S. 44 (2011), is a United States Supreme Court case in which the Court upheld a Treasury Department regulation on the grounds that the courts should defer to government agencies in tax cases in absence of an unreasonable decision on the part of the agency.

    Under the Federal Insurance Contributions Act (FICA), students and their educational employers are exempted from paying Social Security taxes. The Treasury Department issued a regulation in 2004, declaring those who worked more than 40 hours a week were ineligible for such an exemption. The Mayo Foundation filed suit to challenge the regulation and for a refund of the taxes it had paid on its medical residents—recently graduated physicians, who work more than full-time providing patient care but who are still considered trainees by the medical profession. The District Court ruled for the Mayo Foundation and struck the regulation, but was reversed by the Court of Appeals. (Full article...)
  • Image 3 Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. BPA is produced on an industrial scale by the condensation reaction of phenol and acetone. Global production in 2022 was estimated to be in the region of 10 million tonnes. BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 65–70% of all BPA production. The manufacturing of epoxy resins and vinyl ester resins account for 25–30% of BPA use. The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. It is not a plasticizer, although it is often wrongly labelled as such. (Full article...)

    Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. BPA is produced on an industrial scale by the condensation reaction of phenol and acetone. Global production in 2022 was estimated to be in the region of 10 million tonnes.

    BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 65–70% of all BPA production. The manufacturing of epoxy resins and vinyl ester resins account for 25–30% of BPA use. The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. It is not a plasticizer, although it is often wrongly labelled as such. (Full article...)
  • Image 4 Oral herpes of the lower lip. Note the blisters in a group marked by an arrow. Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes, though other forms also exist. Oral herpes involves the face or mouth. It may result in small blisters in groups, often called cold sores or fever blisters, or may just cause a sore throat. Genital herpes involves the genitalia. It may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. (Full article...)

    Oral herpes of the lower lip. Note the blisters in a group marked by an arrow.

    Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes, though other forms also exist.

    Oral herpes involves the face or mouth. It may result in small blisters in groups, often called cold sores or fever blisters, or may just cause a sore throat. Genital herpes involves the genitalia. It may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. (Full article...)
  • Image 5 Curie, c. 1920 Maria Salomea Skłodowska-Curie[a] (Polish: [ˈmarja salɔˈmɛa skwɔˈdɔfska kʲiˈri] ⓘ; née Skłodowska; 7 November 1867 – 4 July 1934), known simply as Marie Curie (/ˈkjʊəri/ KURE-ee; French: [maʁi kyʁi]), was a Polish and naturalised-French physicist and chemist who conducted pioneering research on radioactivity. She was the first woman to win a Nobel Prize, the first person to win a Nobel Prize twice, and the only person to win a Nobel Prize in two scientific fields. Her husband, Pierre Curie, was a co-winner of her first Nobel Prize, making them the first married couple to win the Nobel Prize and launching the Curie family legacy of five Nobel Prizes. She was, in 1906, the first woman to become a professor at the University of Paris. She was born in Warsaw, in what was then the Kingdom of Poland, part of the Russian Empire. She studied at Warsaw's clandestine Flying University and began her practical scientific training in Warsaw. In 1891, aged 24, she followed her elder sister Bronisława to study in Paris, where she earned her higher degrees and conducted her subsequent scientific work. In 1895, she married the French physicist Pierre Curie, and she shared the 1903 Nobel Prize in Physics with him and with the physicist Henri Becquerel for their pioneering work developing the theory of "radioactivity"—a term she coined. In 1906, Pierre Curie died in a Paris street accident. Marie won the 1911 Nobel Prize in Chemistry for her discovery of the elements polonium and radium, using techniques she invented for isolating radioactive isotopes. Under her direction, the world's first studies were conducted into the treatment of neoplasms by the use of radioactive isotopes. She founded the Curie Institute in Paris in 1920, and the Curie Institute in Warsaw in 1932; both remain major medical research centres. During World War I, she developed mobile radiography units to provide X-ray services to field hospitals. (Full article...)

    Curie, c. 1920

    Maria Salomea Skłodowska-Curie[a] (Polish: [ˈmarja salɔˈmɛa skwɔˈdɔfska kʲiˈri] ⓘ; née Skłodowska; 7 November 1867 – 4 July 1934), known simply as Marie Curie (/ˈkjʊəri/ KURE-ee; French: [maʁi kyʁi]), was a Polish and naturalised-French physicist and chemist who conducted pioneering research on radioactivity. She was the first woman to win a Nobel Prize, the first person to win a Nobel Prize twice, and the only person to win a Nobel Prize in two scientific fields. Her husband, Pierre Curie, was a co-winner of her first Nobel Prize, making them the first married couple to win the Nobel Prize and launching the Curie family legacy of five Nobel Prizes. She was, in 1906, the first woman to become a professor at the University of Paris.

    She was born in Warsaw, in what was then the Kingdom of Poland, part of the Russian Empire. She studied at Warsaw's clandestine Flying University and began her practical scientific training in Warsaw. In 1891, aged 24, she followed her elder sister Bronisława to study in Paris, where she earned her higher degrees and conducted her subsequent scientific work. In 1895, she married the French physicist Pierre Curie, and she shared the 1903 Nobel Prize in Physics with him and with the physicist Henri Becquerel for their pioneering work developing the theory of "radioactivity"—a term she coined. In 1906, Pierre Curie died in a Paris street accident. Marie won the 1911 Nobel Prize in Chemistry for her discovery of the elements polonium and radium, using techniques she invented for isolating radioactive isotopes. Under her direction, the world's first studies were conducted into the treatment of neoplasms by the use of radioactive isotopes. She founded the Curie Institute in Paris in 1920, and the Curie Institute in Warsaw in 1932; both remain major medical research centres. During World War I, she developed mobile radiography units to provide X-ray services to field hospitals. (Full article...)
  • Image 6 Malpuech facial clefting syndrome, also called Malpuech syndrome or Gypsy type facial clefting syndrome, is a rare congenital syndrome. It is characterized by facial clefting (any type of cleft in the bones and tissues of the face, including a cleft lip and palate), a caudal appendage (a "human tail"), growth deficiency, intellectual and developmental disability, and abnormalities of the renal system (kidneys) and the male genitalia. Abnormalities of the heart, and other skeletal malformations may also be present. The syndrome was initially described by Georges Malpuech and associates in 1983. It is thought to be genetically related to Juberg-Hayward syndrome. Malpuech syndrome has also been considered as part of a spectrum of congenital genetic disorders associated with similar facial, urogenital and skeletal anomalies. Termed "3MC syndrome", this proposed spectrum includes Malpuech, Michels and Mingarelli-Carnevale (OSA) syndromes. Mutations in the COLLEC11 and MASP1 genes are believed to be a cause of these syndromes. The incidence of Malpuech syndrome is unknown. The pattern of inheritance is autosomal recessive, which means a defective (mutated) gene associated with the syndrome is located on an autosome, and the syndrome occurs when two copies of this defective gene are inherited. (Full article...)
    Malpuech facial clefting syndrome, also called Malpuech syndrome or Gypsy type facial clefting syndrome, is a rare congenital syndrome. It is characterized by facial clefting (any type of cleft in the bones and tissues of the face, including a cleft lip and palate), a caudal appendage (a "human tail"), growth deficiency, intellectual and developmental disability, and abnormalities of the renal system (kidneys) and the male genitalia. Abnormalities of the heart, and other skeletal malformations may also be present. The syndrome was initially described by Georges Malpuech and associates in 1983. It is thought to be genetically related to Juberg-Hayward syndrome. Malpuech syndrome has also been considered as part of a spectrum of congenital genetic disorders associated with similar facial, urogenital and skeletal anomalies. Termed "3MC syndrome", this proposed spectrum includes Malpuech, Michels and Mingarelli-Carnevale (OSA) syndromes. Mutations in the COLLEC11 and MASP1 genes are believed to be a cause of these syndromes. The incidence of Malpuech syndrome is unknown. The pattern of inheritance is autosomal recessive, which means a defective (mutated) gene associated with the syndrome is located on an autosome, and the syndrome occurs when two copies of this defective gene are inherited. (Full article...)
  • Image 7 A Wistar laboratory rat Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals, such as model organisms, in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry. The focus of animal testing varies on a continuum from pure research, focusing on developing fundamental knowledge of an organism, to applied research, which may focus on answering some questions of great practical importance, such as finding a cure for a disease. Examples of applied research include testing disease treatments, breeding, defense research, and toxicology, including cosmetics testing. In education, animal testing is sometimes a component of biology or psychology courses. Research using animal models has been central to most of the achievements of modern medicine. It has contributed to most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. The results have included the near-eradication of polio and the development of organ transplantation, and have benefited both humans and animals. From 1910 to 1927, Thomas Hunt Morgan's work with the fruit fly Drosophila melanogaster identified chromosomes as the vector of inheritance for genes, and Eric Kandel wrote that Morgan's discoveries "helped transform biology into an experimental science". Research in model organisms led to further medical advances, such as the production of the diphtheria antitoxin and the 1922 discovery of insulin and its use in treating diabetes, which had previously meant death. Modern general anaesthetics such as halothane were also developed through studies on model organisms, and are necessary for modern, complex surgical operations. Other 20th-century medical advances and treatments that relied on research performed in animals include organ transplant techniques, the heart-lung machine, antibiotics, and the whooping cough vaccine. (Full article...)

    A Wistar laboratory rat

    Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals, such as model organisms, in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry. The focus of animal testing varies on a continuum from pure research, focusing on developing fundamental knowledge of an organism, to applied research, which may focus on answering some questions of great practical importance, such as finding a cure for a disease. Examples of applied research include testing disease treatments, breeding, defense research, and toxicology, including cosmetics testing. In education, animal testing is sometimes a component of biology or psychology courses.

    Research using animal models has been central to most of the achievements of modern medicine. It has contributed to most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. The results have included the near-eradication of polio and the development of organ transplantation, and have benefited both humans and animals. From 1910 to 1927, Thomas Hunt Morgan's work with the fruit fly Drosophila melanogaster identified chromosomes as the vector of inheritance for genes, and Eric Kandel wrote that Morgan's discoveries "helped transform biology into an experimental science". Research in model organisms led to further medical advances, such as the production of the diphtheria antitoxin and the 1922 discovery of insulin and its use in treating diabetes, which had previously meant death. Modern general anaesthetics such as halothane were also developed through studies on model organisms, and are necessary for modern, complex surgical operations. Other 20th-century medical advances and treatments that relied on research performed in animals include organ transplant techniques, the heart-lung machine, antibiotics, and the whooping cough vaccine. (Full article...)
  • Image 8 The term Vitamin E refers to a group of eight molecular-structure related compounds that include four tocopherols and four tocotrienols. The tocopherols function as fat-soluble antioxidants which may help protect cell membranes from reactive oxygen species. Vitamin E is classified as an essential nutrient for humans. Various government organizations recommend that adults consume between 3 and 15 mg per day, while a 2016 worldwide review reported a median dietary intake of 6.2 mg per day. Sources rich in vitamin E include seeds, nuts, seed oils, peanut butter, vitamin E-fortified foods and dietary supplements. Symptomatic vitamin E deficiency is rare, is usually caused by an underlying problem with digesting dietary fat rather than from a diet low in vitamin E. Deficiency can cause neurological disorders. Tocopherols and tocotrienols both occur in α (alpha), β (beta), γ (gamma), and δ (delta) forms, as determined by the number and position of methyl groups on the chromanol ring. All eight of these vitamers feature a chromane double ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals, and a hydrophobic side chain that allows for penetration into biological membranes. Both natural and synthetic tocopherols are subject to oxidation, so dietary supplements are esterified, creating tocopheryl acetate for stability purposes. (Full article...)

    The term Vitamin E refers to a group of eight molecular-structure related compounds that include four tocopherols and four tocotrienols. The tocopherols function as fat-soluble antioxidants which may help protect cell membranes from reactive oxygen species. Vitamin E is classified as an essential nutrient for humans. Various government organizations recommend that adults consume between 3 and 15 mg per day, while a 2016 worldwide review reported a median dietary intake of 6.2 mg per day. Sources rich in vitamin E include seeds, nuts, seed oils, peanut butter, vitamin E-fortified foods and dietary supplements. Symptomatic vitamin E deficiency is rare, is usually caused by an underlying problem with digesting dietary fat rather than from a diet low in vitamin E. Deficiency can cause neurological disorders.

    Tocopherols and tocotrienols both occur in α (alpha), β (beta), γ (gamma), and δ (delta) forms, as determined by the number and position of methyl groups on the chromanol ring. All eight of these vitamers feature a chromane double ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals, and a hydrophobic side chain that allows for penetration into biological membranes. Both natural and synthetic tocopherols are subject to oxidation, so dietary supplements are esterified, creating tocopheryl acetate for stability purposes. (Full article...)
  • Image 9 Skeletal formula of noradrenaline Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. The name "noradrenaline" (from Latin ad, "near", and ren, "kidney") is more commonly used in the United Kingdom, whereas "norepinephrine" (from Ancient Greek ἐπῐ́ (epí), "upon", and νεφρός (nephrós), "kidney") is usually preferred in the United States. "Norepinephrine" is also the international nonproprietary name given to the drug. Regardless of which name is used for the substance itself, parts of the body that produce or are affected by it are referred to as noradrenergic. The general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety. In the rest of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and gastrointestinal motility. (Full article...)

    Skeletal formula of noradrenaline

    Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. The name "noradrenaline" (from Latin ad, "near", and ren, "kidney") is more commonly used in the United Kingdom, whereas "norepinephrine" (from Ancient Greek ἐπῐ́ (epí), "upon", and νεφρός (nephrós), "kidney") is usually preferred in the United States. "Norepinephrine" is also the international nonproprietary name given to the drug. Regardless of which name is used for the substance itself, parts of the body that produce or are affected by it are referred to as noradrenergic.

    The general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety. In the rest of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and gastrointestinal motility. (Full article...)
  • Image 10 A Book of Medical Discourses (1883) by Rebecca Lee Crumpler, M.D. Rebecca Lee Crumpler (born Rebecca Davis, February 8, 1831 – March 9, 1895) was an American physician, nurse and author. After studying at the New England Female Medical College, in 1864 she became the first African American woman to become a doctor of medicine in the United States. Crumpler was also one of the first female physician authors in the nineteenth century. In 1883, she published A Book of Medical Discourses. The book has two parts that cover the prevention and cure of infantile bowel complaints, and the life and growth of human beings. Dedicated to nurses and mothers, it focuses on maternal and pediatric medical care and was among the first publications written by an African American on the subject of medicine. Crumpler graduated from medical college at a time when very few African Americans were permitted to attend medical college or publish books. Crumpler first practiced medicine in Boston, primarily serving poor women and children. After the American Civil War ended in 1865, she moved to Richmond, Virginia, believing treating women and children was an ideal way to perform missionary work. Crumpler worked for the Freedmen's Bureau to provide medical care for freedmen and freedwomen. (Full article...)
    A Book of Medical Discourses (1883) by Rebecca Lee Crumpler, M.D.

    Rebecca Lee Crumpler (born Rebecca Davis, February 8, 1831 – March 9, 1895) was an American physician, nurse and author. After studying at the New England Female Medical College, in 1864 she became the first African American woman to become a doctor of medicine in the United States. Crumpler was also one of the first female physician authors in the nineteenth century. In 1883, she published A Book of Medical Discourses. The book has two parts that cover the prevention and cure of infantile bowel complaints, and the life and growth of human beings. Dedicated to nurses and mothers, it focuses on maternal and pediatric medical care and was among the first publications written by an African American on the subject of medicine.

    Crumpler graduated from medical college at a time when very few African Americans were permitted to attend medical college or publish books. Crumpler first practiced medicine in Boston, primarily serving poor women and children. After the American Civil War ended in 1865, she moved to Richmond, Virginia, believing treating women and children was an ideal way to perform missionary work. Crumpler worked for the Freedmen's Bureau to provide medical care for freedmen and freedwomen. (Full article...)
  • Image 11 Bust of Arroyo in Palencia, Spain Trinidad Arroyo Villaverde (26 May 1872 – 28 September 1959) was a Spanish ophthalmologist. She was the first woman ophthalmologist in Spain and the third to receive a doctorate degree, obtaining her doctorate in 1896. She was a teacher and researcher at the University of Madrid, and she operated an ophthalmology practice with her husband Manuel Márquez. They were forced to flee the country in 1939 due to the Spanish Civil War, and they resumed their practice in Mexico City, where they lived for the rest of their lives. Arroyo was politically active while living in Spain, serving as vice president of a women's anti-fascist association and participating in several feminist organizations. It was this, as well as her alleged ties with the Soviet Union, that made her and her husband targets of the Nationalist faction in the Spanish Civil War. She was also one of the first women in Spain to vote in an election, a right granted to her by her position in the university faculty. (Full article...)

    Bust of Arroyo in Palencia, Spain

    Trinidad Arroyo Villaverde (26 May 1872 – 28 September 1959) was a Spanish ophthalmologist. She was the first woman ophthalmologist in Spain and the third to receive a doctorate degree, obtaining her doctorate in 1896. She was a teacher and researcher at the University of Madrid, and she operated an ophthalmology practice with her husband Manuel Márquez. They were forced to flee the country in 1939 due to the Spanish Civil War, and they resumed their practice in Mexico City, where they lived for the rest of their lives.

    Arroyo was politically active while living in Spain, serving as vice president of a women's anti-fascist association and participating in several feminist organizations. It was this, as well as her alleged ties with the Soviet Union, that made her and her husband targets of the Nationalist faction in the Spanish Civil War. She was also one of the first women in Spain to vote in an election, a right granted to her by her position in the university faculty. (Full article...)
  • Image 12 AXH domain of Ataxin 1 Spinocerebellar ataxia type 1 (SCA1) is a rare autosomal dominant disorder, which, like other spinocerebellar ataxias, is characterized by neurological symptoms including dysarthria, hypermetric saccades, and ataxia of gait and stance. This cerebellar dysfunction is progressive and permanent. First onset of symptoms is normally between 30 and 40 years of age, though juvenile onset can occur. Death typically occurs within 10 to 30 years from onset. SCA1 is typically inherited from the parents in an autosomal dominant regime; the children of a person with the disease have a 50% chance of inheriting it themselves, and new mutations can occur in some cases. It is caused by an expanded number of trinucleotide repeats in the polyglutamine tract of the ATXN1 gene, which encodes the ataxin 1 protein. This expansion results in a larger than normal number of repeats of the nucleotide sequence cytosine, adenine, guanine, or CAG, in the gene which, in turn, results in a larger than normal number of consecutive glutamine amino acid residues in the protein. This mutant protein causes degradation in certain types of neurons, like Purkinje neurons, which are common in the cerebellum, spinal cord, and related parts of the brain. While the mechanism is not fully understood, it is suspected that changes in the interactions between ataxin 1 and other proteins result in a toxic gain of function. (Full article...)

    AXH domain of Ataxin 1

    Spinocerebellar ataxia type 1 (SCA1) is a rare autosomal dominant disorder, which, like other spinocerebellar ataxias, is characterized by neurological symptoms including dysarthria, hypermetric saccades, and ataxia of gait and stance. This cerebellar dysfunction is progressive and permanent. First onset of symptoms is normally between 30 and 40 years of age, though juvenile onset can occur. Death typically occurs within 10 to 30 years from onset.

    SCA1 is typically inherited from the parents in an autosomal dominant regime; the children of a person with the disease have a 50% chance of inheriting it themselves, and new mutations can occur in some cases. It is caused by an expanded number of trinucleotide repeats in the polyglutamine tract of the ATXN1 gene, which encodes the ataxin 1 protein. This expansion results in a larger than normal number of repeats of the nucleotide sequence cytosine, adenine, guanine, or CAG, in the gene which, in turn, results in a larger than normal number of consecutive glutamine amino acid residues in the protein. This mutant protein causes degradation in certain types of neurons, like Purkinje neurons, which are common in the cerebellum, spinal cord, and related parts of the brain. While the mechanism is not fully understood, it is suspected that changes in the interactions between ataxin 1 and other proteins result in a toxic gain of function. (Full article...)
  • Image 13 The Xinxiu bencao (Chinese: 新修本草; pinyin: Xīnxiū běncǎo), also known as the Tang bencao (Chinese: 唐本草; pinyin: Táng běncǎo), is a Chinese pharmacopoeia written in the Tang dynasty by a team of officials and physicians headed by editor-in-chief Su Jing [zh]. It borrowed heavily from—and expanded upon—the earlier Bencao jing jizhu [zh] by Tao Hongjing. The text was first published in 659; although it is now considered lost in China, at least one copy exists in Japan, where the text had been transmitted to in 721. (Full article...)
    The Xinxiu bencao (Chinese: 新修本草; pinyin: Xīnxiū běncǎo), also known as the Tang bencao (Chinese: 唐本草; pinyin: Táng běncǎo), is a Chinese pharmacopoeia written in the Tang dynasty by a team of officials and physicians headed by editor-in-chief Su Jing [zh]. It borrowed heavily from—and expanded upon—the earlier Bencao jing jizhu [zh] by Tao Hongjing. The text was first published in 659; although it is now considered lost in China, at least one copy exists in Japan, where the text had been transmitted to in 721. (Full article...)
  • Image 14 Giemsa-stained smears of Plasmodium knowlesi infecting human red blood cells Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. It is found throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. P. knowlesi is a eukaryote in the phylum Apicomplexa, genus Plasmodium, and subgenus Plasmodium. It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates. Humans infected with P. knowlesi can develop uncomplicated or severe malaria similar to that caused by Plasmodium falciparum. Diagnosis of P. knowlesi infection is challenging as P. knowlesi very closely resembles other species that infect humans. Treatment is similar to other types of malaria, with chloroquine or artemisinin combination therapy typically recommended. P. knowlesi malaria is an emerging disease previously thought to be rare in humans, but increasingly recognized as a major health burden in Southeast Asia. (Full article...)

    Giemsa-stained smears of Plasmodium knowlesi infecting human red blood cells

    Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. It is found throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. P. knowlesi is a eukaryote in the phylum Apicomplexa, genus Plasmodium, and subgenus Plasmodium. It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates.

    Humans infected with P. knowlesi can develop uncomplicated or severe malaria similar to that caused by Plasmodium falciparum. Diagnosis of P. knowlesi infection is challenging as P. knowlesi very closely resembles other species that infect humans. Treatment is similar to other types of malaria, with chloroquine or artemisinin combination therapy typically recommended. P. knowlesi malaria is an emerging disease previously thought to be rare in humans, but increasingly recognized as a major health burden in Southeast Asia. (Full article...)
  • Image 15 Frances Kathleen Oldham Kelsey CM (née Oldham; July 24, 1914 – August 7, 2015) was a Canadian-American pharmacologist and physician. As a reviewer for the U.S. Food and Drug Administration (FDA), she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding the drug's safety. Her concerns proved to be justified when it was shown that thalidomide caused serious birth defects. Kelsey's career intersected with the passage of laws strengthening FDA oversight of pharmaceuticals. Kelsey was the second woman to receive the President's Award for Distinguished Federal Civilian Service, awarded to her by John F. Kennedy in 1962. (Full article...)

    Frances Kathleen Oldham Kelsey CM (née Oldham; July 24, 1914 – August 7, 2015) was a Canadian-American pharmacologist and physician. As a reviewer for the U.S. Food and Drug Administration (FDA), she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding the drug's safety. Her concerns proved to be justified when it was shown that thalidomide caused serious birth defects. Kelsey's career intersected with the passage of laws strengthening FDA oversight of pharmaceuticals. Kelsey was the second woman to receive the President's Award for Distinguished Federal Civilian Service, awarded to her by John F. Kennedy in 1962. (Full article...)
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Did you know – show different entries

  • ...that during the "Age of Heroic Medicine" (1780-1850), educated professional physicians aggressively practiced "heroic medicine", including bloodletting (venesection), intestinal purging (calomel), vomiting (tartar emetic), profuse sweating (diaphoretics) and blistering? These medical treatments were well-intentioned, and often well-accepted by the medical community, but were actually harmful to the patient.
  • ...thalidomide is a drug that was sold during the late 1950s and 1960s to pregnant women as an antiemetic? It was later found to be teratogenic, causing amelia and phocomelia. However, it is still used for other indications such as for leprosy and multiple myeloma, with close regulation through the System for Thalidomide Education and Prescribing Safety (STEPS) program.
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